Three rounds of clinical trials are designed to test progressively larger numbers of patients.

• A. One round.
• B. Two rounds.
• C. Three rounds of clinical trials test progressively larger numbers of patients.
• D. Four rounds.

Answer: (C)

Clinical development uses a sequence of trials that enroll progressively more participants in each stage. The first phase tests safety and dosing in a small group, the second phase expands to assess efficacy and continue safety in a larger group, and the third phase enrolls a much larger population to confirm effectiveness and monitor safety across diverse patients. This structure naturally involves three rounds with increasing numbers of participants, which is why the statement describing three rounds is the best fit.

Saying there’s only one round wouldn’t capture the stepwise buildup in data and safety information. Two rounds would miss the full scale of evaluation seen in the standard three-phase process. Four rounds would imply adding a later stage (post-approval surveillance) beyond the three major trial phases discussed, which isn’t the focus here.